Amgen Lumakras (sotorasib) 120 mg Tablets, 120 tablets

Description

Before taking Lumakras

Before you start treatment, tell your healthcare provider about all your medical conditions, including if you:

• have liver problems
• have lung or breathing problems other than lung cancer
• are pregnant or plan to become pregnant. It is not known if Lumakras will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if Lumakras passes into your breast milk. Do not breastfeed during treatment, and for 1 week after the final dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, dietary and herbal supplements. Lumakras can affect the way some other medicines work, and some other medicines can affect the way Lumakras works.

How should I take Lumakras?

• Take Lumakras exactly as your healthcare provider tells you to take it. Do not change your dose or stop taking Lumakras unless your healthcare provider tells you to.
• Take Lumakras tablets 1 time each day, at about the same time each day.
• Take the tablets with or without food.
• Swallow the tablets whole. Do not chew, crush, or split tablets.
• If you cannot swallow the tablets whole:
  • Place your daily dose in a glass of 4 ounces (120 mL) of non-carbonated, room temperature water without crushing the tablets. Do not use any other liquids.
  • Stir until the tablets are in small pieces (the tablets will not completely dissolve). The color of the mixture may be pale yellow to bright yellow.
  • Drink the tablet and water mixture right away or within 2 hours of preparing. Do not chew pieces of the tablet.
  • Rinse the glass with an additional 4 ounces (120 mL) of water and drink to make sure that you have taken the full dose.
• If you do not drink the mixture right away, stir the mixture again before drinking.
• If you take an antacid medicine, take Lumakras either 4 hours before or 10 hours after the antacid.
• If you miss a dose of Lumakras, take the dose as soon as you remember. If it has been more than 6 hours, do not take the dose. Take your next dose at your regularly scheduled time the next day. Do not take 2 doses at the same time to make up for a missed dose.
• If you vomit after taking a dose, do not take an extra dose. Take your next dose at your regularly scheduled time the next day.

Lumakras side effects

Lumakras may cause serious side effects, including:

• Liver problems. Lumakras may cause abnormal liver blood test results. Your healthcare provider should do blood tests before starting, and during treatment to check your liver function. Tell your healthcare provider right way if you get any signs or symptoms of liver problems, including:
  • your skin or the white part of your eyes turns yellow (jaundice)
  • dark or “tea-colored” urine
  • light-colored stools (bowel movements)
  • tiredness or weakness
  • nausea or vomiting
  • bleeding or bruising
  • loss of appetite
  • pain, aching, or tenderness on the right side of your stomach-area (abdomen)
• Lung or breathing problems. Lumakras may cause inflammation of the lungs that can lead to death. Tell your healthcare provider or get emergency medical help right away if you have new or worsening shortness of breath, cough or fever.
  Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment if you develop side effects.