Mounjaro Tirzepatide 10 mg/0.5 mL Injection Prefilled Pens

Description

Mounjaro works like two natural hormones in our bodies, called GIP and GLP-1, which help control appetite, blood sugar levels, and digestion. When Mounjaro binds to GIP and the GLP-1 receptors, the pancreas releases more insulin, lowers the amount of sugar your liver makes, and slows the rate food passes through your body, making you feel full longer. This helps lower blood sugar levels and helps weight loss. Mounjaro is a GIP and GLP-1 receptor agonist. Mounjaro’s mechanism of action is by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors.

What are the side effects of Mounjaro?

Common Mounjaro side effects

The most common Mounjaro side effects include nausea, diarrhea, decreased appetite, vomiting, constipation, heartburn (dyspepsia), and abdominal pain, which affects 5% or more patients.

Stomach or gastrointestinal Mounjaro side effects are common but tend to be mild and improve after a few weeks in most people and do not interfere with long-term treatment. Stomach side effects can be more common with higher doses.

The most common gastrointestinal Mounjaro side effect is nausea, which occurs in about 12% to 18% of people.

• Other side effects include vomiting (5% to 9%), diarrhea (12% to 17%), stomach-area pain (5% to 6%), and constipation (6% to 7%).
• These side effects occurred at rates higher than the placebo-treated groups (receiving an inactive treatment).

More patients receiving Mounjaro 5mg (3.0%), 10 mg (5.4%), and 15mg (6.6%) discontinued treatment due to stomach side effects than patients receiving placebo (0.4%).

Stomach side effects usually occur at the beginning of treatment and if your dose is increased too quickly. Because of this, your healthcare provider will slowly increase your dose every 4 weeks as needed until you reach your target dose. You can take this medicine with or without meals.

Tips for managing stomach Mounjaro side effects

Following these tips may help you manage stomach Mounjaro side effects:

• eat more slowly
• eat smaller meals
• chose more bland, low-fat foods (like crackers, toast and rice)
• avoid greasy, fried foods or sugar treats
• eat foods that contain water (like soup or gelatin)
• don’t lie down right after eating
• drink clear or ice-cold liquids
• if possible, go outside for fresh air if you feel sick to your stomach

Serious Mounjaro side effects

Serious Mounjaro side effects include severe stomach problems, acute kidney damage, gallbladder disease, acute pancreatitis (inflamed pancreas), serious allergic reactions, low blood sugar levels (hypoglycemia), diabetic retinopathy issues in type 2 diabetics, and food or liquid getting into the lungs during anesthesia or deep sedation.

Stop using this medicine and get emergency medical help if you have:

• signs of an allergic reaction: hives; difficulty breathing; feeling light-headed; swelling of your face, lips, tongue, or throat; or
• pancreatitis with symptoms of severe pain in your upper stomach spreading to your back, nausea and vomiting.

Call your doctor at once if you have:

• severe stomach problems;
• eye side effects or vision changes, including blurry vision or blurred vision;
• signs of a thyroid tumor symptoms may include swelling or a lump in your neck, trouble swallowing, a hoarse voice, or if you feel short of breath;
• gallbladder problem with symptoms including chalky-colored stools, stomach pain after eating, nausea, heartburn, bloating, and severe upper stomach pain that may spread to your back;
• low blood sugar symptoms may include headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or
• kidney problems with little or no urination, swelling in your feet or ankles, feeling tired or short of breath.