IPF causes the lung tissue to thicken, stiffen and scar over time. Scarring prevents oxygen from being transported in adequate quantities from the lungs into the bloodstream, causing breathing problems. Ofev helps reduce scarring and stiffening of the lungs.
In addition to IPF, there are other diseases that cause thickening, stiffening and, over time, scarring of the lung tissue (pulmonary fibrosis) with gradual worsening (progressive phenotype). This includes diseases such as hypersensitivity lung, autoimmune ILD (e.g. ILD associated with rheumatoid arthritis), non-specific idiopathic interstitial pneumonia, unclassified idiopathic interstitial pneumonia and other ILDs. Ofev helps reduce scarring and stiffening of the lungs.
Systemic sclerosis, also known as scleroderma (SSc), is a rare chronic autoimmune disease that affects the connective tissue of different parts of the body. SSc causes fibrosis (scarring and stiffening) of the skin, lungs, and other internal organs. When the lungs are affected by fibrosis, it is called interstitial lung disease (ILD) and the pathology is called SSc-ILD. Fibrosis reduces the lungs’ ability to transport oxygen to the blood and reduces breathing capacity. Ofev helps reduce further scarring and stiffening of the lungs.
The active substance is nintedanib.
1 soft capsule contains 100 mg or 150 mg of nintedanib in the form of nintedanib hexilate.
Always take Ofev carefully following the instructions of your doctor or pharmacist. If you have any doubts, ask your doctor or pharmacist.
The recommended dose of Ofev is one 150 mg capsule twice a day to be taken with food at intervals of approximately 12 hours, always at the same time, for example one capsule in the morning and one in the evening.
Take the capsules with a glass of water and swallow them whole (do not chew the capsules).
The capsules must not be opened or crushed. If you come into contact with the contents of a capsule, wash your hands immediately and thoroughly.
Do not stop treatment without first consulting your doctor. It is important that you continue to take the medicine for the duration indicated by your doctor.
Do not change the prescribed dosage on your own initiative. If you think that the action of the medicine is too weak or too strong, talk to your doctor or pharmacist.
Contact your doctor or pharmacist immediately.
Do not take a double dose if you forget to take the previous dose. Take your next dose at the next scheduled time as scheduled, and at the dose recommended by your doctor or pharmacist.
The use and safety of Ofev in children and adolescents under 18 years of age have not been investigated so far. Children and adolescents should therefore not take Ofev.
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